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Finding the genetic changes in bacteria

MMM researchers have shown how powerful new DNA analysis techniques can detect mutations in bacteria which cause difficult to treat infections.

In research published in Nature Microbiology, they used the technique - 'Bacterial Genome-Wide Association Studies', showing  that using the bacterial 'family tree' could improve standard methods. They demonstrated they could detect mutations already known to make these bacteria resistant to antibiotics, and could also pick up new mutations not previously known to researchers.

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Global team aim for faster, more effective TB Diagnosis

As World TB day (24 March) marks global efforts to eliminate tuberculosis as a public health problem by 2035, Oxford University researchers, in partnership with Public Health England (PHE), will lead a new worldwide collaboration called CRyPTIC to speed up diagnosis of the disease.
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Gut Flora Art Exhibition

Artistic work from MMM is currently on display in the John Radcliffe Hospital. The works explore the ecosystem of the gut microbes, and how they are affected by antibiotics.
The work is on display until the end of April.
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About Modernising Medical Microbiology

Modernising Medical Microbiology is a research group aiming to transform how we analyse and treat infections, to improve patient care.

We aim to:

1) Modernise the way we analyse infections, bringing cutting-edge scientific techniques to clinical care.

2) Transform they way we study the treatment of patients with infections, using large databases of hospital electronic information, to identify trends in how infections are behaving, and ways patient care can be improved.

3) Use techniques such as DNA analysis of bacteria and viruses to better understand how infections spread, how to treat them, and how to prevent them in the future.

4) Study how bacteria become resistant to antibiotics, and more difficult to treat, and how to prevent this.

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Modernising Medical Microbiology studies a number of infections, in particular Staphylococcus aureus (including MRSA), Clostridium difficile (C. diff), Mycobacterium tuberculosis (TB),  and the Enterobacteriaceae family (Escherichia coli, Klebsiella species and others).  You can learn more about these bacteria here